Pilot study of measuring cardiac volume and cardiac function in patients with resectable esophagus carcinoma during pre-operative chemoradiatio

Completed

• Conditions: esophageal cancer; 10017990

• Registration Number: NL-OMON38490
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 23

Inclusion Criteria

patients with esophageal cancer who are planned to be treated with preoperative chemoradiation

Exclusion Criteria

cardiac failure NYHA class 3 and 4
previous radiotherapy

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in cardiac volume at baseline compared to weekly measurement during<br /><br>chemoradiation </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Change in inferior vena cava diameter at the end of chemoradiation compared<br /><br>to baseline<br /><br>- Changes in myocardial strain and strain rate at the end of chemoradiation<br /><br>compared to baseline<br /><br>- Weekly changes in concentration of Creatine Kinase (CK), Creatine Kinase<br /><br>Muscle type and Brain type (CK-MB), troponin, N-terminal-pro-natriuretic<br /><br>peptide (NT-pro-BNP)<br /><br>- Change in LVEF at the end of chemoradiation compared to baseline<br /><br>- Change in New York Heart Association (NYHA) score at baseline compared to<br /><br>weekly measurements during treatment.<br /><br>*</p><br>