A Comparative study of vital parameters of two different IV anaesthetic agents and combination of both during intubation

Phase 2

Not yet recruiting

Conditions: Encounter for examination and observation for unspecified reason, (2) ICD-10 Condition: R69||Illness, unspecified, (3) ICD-10 Condition: R69||Illness, unspecified, (4) ICD-10 Condition: R69||Illness, unspecified,

Registration Number: CTRI/2024/02/062662

Lead Sponsor: Civil hospital Ahmedabad

Brief Summary: Endo-tracheal intubation is the gold standard and safestmethod for protecting the airway, delivering anesthetic gases and ensuringprotection against aspiration. Stress response during laryngoscopy andintubation leads to hemodynamic changes like hypertension and ischemic heartdisease. The unavoidable effects of laryngoscopy and tracheal intubationinclude dysrhythmia, hypertension, myocardial ischemia, infarction, hypoxia, hypercapnia and increased intracranial pressure and increased intraocular pressure.

There is no ideal induction agent in term of providing astable hemodynamics during endotracheal intubation. Also, there are very fewpublished studies in the literature that have compared the physiological effectof combination of induction agents during laryngoscopy and intubation.

Propofol is one the commonly used drug for induction ofgeneral anesthesia. This is a short acting intravenous anesthetic agent.Unwanted complication associated with this drug is hemodynamic instability andcardiovascular complications. Propofol can lead to bradycardia by increasingthe production and release of nitrous oxide. It also causes pain at injection site.

Etomidate is a hypnotic agent which is cardio-stable withno release of histamine. It is short acting drug, used for induction andmaintenance of anesthesia. The most important side effects of etomidate areburning sensation at injection site, myoclonic movements, nausea and vomiting. Induction of anesthesia by Etomidate would lead to a stable hemodynamiccondition while performing laryngoscopy and endotracheal intubation.

Very few studies regarding combination of propofol andetomidate focused on hemodynamic changes during anesthesia induction andintubation are available. This study is planned to evaluate and compare theeffects of etomidate, propofol and combination of etomidate and propofol on hemodynamic parameters during induction, laryngoscopy and endotrachealintubation.

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Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 105

Inclusion Criteria

1.Patients willing to consent for the study 2.Elective surgery under general anaesthesia with endotracheal intubation 3.ASA class 1, 2, 3 4.Either gender.

Exclusion Criteria

1.Difficult airway 2.Pregnancy 3.severe cardiopulmonary or liver disease , hypotension , shock 4.Presence of known primary or secondary adrenal insufficiency 5.Patient on steroid medication 6.Allergic to propofol and etomidate 7.Patients BMI equal or greater than 40kg/m2.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the hemodynamic parameters (HR, SBP,DBP,MBP)	From start of induction till 1hour & thereafter 10 minutes postop

Secondary Outcome Measures

Name	Time	Method
To compare the adverse effects at the time of induction such as myoclonus , pain on injection .	To compare perioperative complications such as intraoperative arrhythmias , desaturation , postoperative nausea & vomiting and thrombophlebitis

Trial Locations

Locations (1): Civil hospital Ahmedabad
🇮🇳
Ahmadabad, GUJARAT, India
Civil hospital Ahmedabad
🇮🇳Ahmadabad, GUJARAT, India
Dr Soundharya T
Principal investigator
8056355004
sindhu66@ymail.com