NCT01127997已完成不适用
The Effect and Mechanisms of the Second-meal Phenomenon in Type 2 Diabetic
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Area under the curve of plasma glucose after meal
研究概览
简要总结
Second-meal phenomenon denotes the effect of a prior meal in decreasing the rise in blood glucose after a subsequent meal. This phenomenon occurs in normal subjects while it is not clear whether it is also observed in type 2 diabetic patients. This study aims to define whether the second-meal phenomenon occurs in type 2 diabetic patients. We will also seek for the mechanism.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 35-70
- •HbA1c 6-8%
- •DM duration less than 5 yrs
排除标准
- •type 1 DM, secondary DM, gestational DM
- •patients using insulin, TZDs
- •patients using corticosteroid, herb medication or other medications affecting glucose tolerance
- •renal dysfunction (Cr > 1.5mg/dL)
- •hepatic dysfunction (LFT > x 3UNL)
- •anemia (Hg < 10g/dL)
- •ischemic heart disease, congestive heart failure
- •severe diabetic complication (CRF, CVA, PDR, gastroparesis)
- •infectious disease
- •malignancy
- •pregnant women
结局指标
主要结局
Area under the curve of plasma glucose after meal
时间窗: 3 months
Compare the post-lunch AUC of glucose between two meal tolerance tests(one after having breakfast, one after not having breakfast)
次要结局
- the mechanism of second-meal phenomenon(3 months)
研究者
研究点 (1)
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