Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome

Not Applicable

Completed

• Conditions: Remote Ischemic Preconditioning; Moyamoya Disease
• Interventions: Procedure: RIPC with RIPostC

• Registration Number: NCT03072914
• Lead Sponsor: Seoul National University Hospital

Brief Summary

In the present study, we evaluated whether RIPC with RIPostC reduce the major neurocomplication in patients undergoing STA-MCA anastomosis.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-02-14
• Study First Submitted QC: 2017-03-02
• Study Start: 2017-03-07
• Study First Posted: 2017-03-07
• Status Verified: 2018-03
• Primary Completion: 2018-07-15
• Study Completion: 2018-07-15
• Last Update Submitted: 2018-08-21
• Last Update Posted: 2018-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

1. American Society of Anesthesiologists
2. Adults 18 to 65 years of age
3. In patients with planned MCA-STA anastomosis under general anesthesia
4. Patients who pre-agreed to the study

Exclusion Criteria

1. If there is a history of peripheral vascular arterial or venous disease
2. If there is a previous history of peripheral nerve disease
3. Other brain or cerebrovascular disease
4. In case of serious cardiovascular disease, pulmonary disease, kidney disease
5. Patients who do not agree with the test

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
RIPC with RIPostC group	RIPC with RIPostC	The sphygmomanometer is closed to the lower limb and the cuff is inflated and the pressure is increased by 30 mmHg higher than the systolic blood pressure of each patient for 5 minutes. The loss of the distal pulse is confirmed by Doppler in the dorsalis pedis pulse. If there is a pulse, increase the pressure until it disappears. After 5 minutes of ischemia time, the cuff is deflated to confirm that the pulse has returned and has a reperfusion time of 5 minutes. A total of 4 cycles of 5 cycles of ischemic time and 5 minutes of reperfusion time are performed. (Estimated total 40 minutes) When the skull is started to close, RIpc with RIPostC group performs RpostC and the method is the same as the above RIPC method. (Estimated total 40 minutes)

Primary Outcome Measures

Name	Time	Method
Number of major adverse event	postoperative one month	hyperperfusion syndrome, hypoperfusion, EDH, SAH, acute infarction

Trial Locations

Locations (1)

Seoul National Univ. Bundang Hospita; 🇰🇷 Seongnam-si, Gyeonggi-do, Korea, Republic of