Impact of remote ischemic preconditioning (RIPC) on kidney function and microRNA-signature of extracellular vesicles following partial nephrectomy: a randomized, prospective trial
Not Applicable
- Conditions
- C64Malignant neoplasm of kidney, except renal pelvis
- Registration Number
- DRKS00030081
- Lead Sponsor
- Marien Hospital Herne
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 170
Inclusion Criteria
kidney tumor
- partial nephrectomy technically feasible
Exclusion Criteria
intraoperative conversion to nephrectomy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative renal function (measured as creatinine, 24 hour-urine, cystatin C und the following biomarkers in plasma and urine: IGFBP7, TIMP-2, KIM-1, NGAL, Vanin-1, NAG, uRBP4, DKK-3) at 24h, 3 and 90 days postoperatively
- Secondary Outcome Measures
Name Time Method Concentration of EV and microRNA-signature from plasma at the following time points:<br>T1: Before anesthesia<br>T2: 5 minutes after RIPC<br>T3: 5 minutes before clamping of renal artery<br>T4: 5 minutes after declamping<br>T5: end of operation