The effect of Remote Ischemic Preconditioning on plasma troponin I appearance after a standardized cycling test in healthy volunteers

• Conditions: Cardiac injury; 10028593

• Registration Number: NL-OMON35150
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

• Age : 18-45 years
• Willing to sign informed consent
• Healthy

Exclusion Criteria

• Hypertension (systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg)
• Any cardiovascular abnormality in past medical history, physical examination or ECG, including prolonged QTc interval.
• Drug abuse
• Alcohol abuse (> 3 units/day)
• Smoking during the last 2 years
• BMI>=30 kg/m2
• Inability to perform bicycle exercise
• The presence of an absolute or relative contra-indication for exercise testing (table 2)
• The presence of diabetes (fasting glucose > 6.9 mmol/l, non-fasting glucose > 11.0 mmol/l; if non-fasting glucose is > 6.9 mmol/l, blood glucose measurement will be repeated in fasting condition and should then not exceed 6.9 mmol/l.)
• Total cholesterol in blood 6.5 mmol/l or higher

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Serum levels of hs-troponin I in response to intensive exercise test. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>