The effect of remote ischaemic preconditioning on lowering postoperative myocardial troponin I release in children with congenital heart disease undergoing cardiopulmonary bypass.

Phase 1

Recruiting

• Conditions: Congenital heart disease witithin neonates; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12607000004460
• Lead Sponsor: Michael Cheung

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-01-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

Neonates undergoing open heart surgery for repair of congenital defects will be recruited. Specifically, children undergoing the arterial switch procedure and the Norwood procedure will be studied.

Exclusion Criteria

Patients with chromosomal defects, associated congenital lung malformations, and haematological disorders and those older than 28 days will be excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative levels of troponin I will be measured from blood samples[Blood samples taken immediately preoperatively and then at 3, 6 and 24 hours postoperatively.]

Secondary Outcome Measures

Name	Time	Method
Cardiac output, lung function, systemic inflammatory response.[Each of these will be assessed at 3, 6 and 24 hours postoperatively.];Inflammatory response in the form of blood levels of TNF-alpha.[Assessed immediately preoperatively.]