Effect of Remote Ischemic Preconditioning on the Incidence of Acute KidneyInjury in Patients Undergoing Coronary Artery Bypass Graft Surgery
Not Applicable
- Conditions
- Condition 1: Acute kidney injury. Condition 2: Remote ischemic preconditioning. Condition 3: Coronary artery bypass graft surgery.
- Registration Number
- IRCT2017110537254N1
- Lead Sponsor
- Vice chancellery for research affairs, Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
Inclusion Criteria:
• Candidate cardiac surgical patients
• Elective or urgent on pump coronary artery bypass grafting (CABG)
• Age 18 to 85 years
• Signed informed consent
Exclusion Criteria
• End-stage renal disease (receiving hemodialysis or glomerular filtration
rate <15 ml/min/1.73m2)
• Peripheral vascular disease
• Severe hepatic disease
• Planned off-pump surgery
• Pregnancy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of postoperative acute kidney injury (AKI). Timepoint: Within the first 72 hours after surgery. Method of measurement: Defined as an elevation of serum creatinine of =0.3 mg/dl or =50% within 72 hours after surgery.
- Secondary Outcome Measures
Name Time Method Duration of hospital stay. Timepoint: Through hospital stay after surgery. Method of measurement: in days.;Duration of ICU stay. Timepoint: Through ICU stay. Method of measurement: in days.;All cause mortality. Timepoint: Through hospital stay after surgery. Method of measurement: number of observed cases.;Requiring hemodialysis. Timepoint: Through hospital stay after surgery. Method of measurement: number of observed cases.;Postoperative liver function. Timepoint: Preoperatively and at 24 h post-surgery. Method of measurement: By measuring serum AST, ALT, T.bilirubin, and albumin.;Incidence of postoperative atrial fibrillation (AF). Timepoint: Within the first 72 hours after surgery. Method of measurement: Defined as the incidence of new-onset AF lasting for five minutes or longer.;Incidence of postoperative stroke. Timepoint: Through hospital stay after surgery. Method of measurement: Defined as a new ischemic or hemorrhagic cerebrovascular accident with neurological deficit lasting >24 h.