The effect of remote ischaemic preconditioning on the late immune response and nervous system

Not Applicable

• Conditions: Remote ischaemic preconditioning is primarily intended for use in cardiac surgery patients; Cardiovascular - Coronary heart disease; Surgery - Surgical techniques

• Registration Number: ACTRN12613000535774
• Lead Sponsor: Jenni Williams

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-05-14
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

Healthy volunteers

Exclusion Criteria

Peripheral vascular disease
Smoking
Regular use of medication
Acute illness (within 1 week of the study visits)
Any cardiac rhythm abnormality
Any condition affecting the autonomic nervous system (eg diabetes, autonomic neuropathy)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Inflammatory cytokine levels in serum, and leukocyte cultures, quantified using a cytometric bead array and flow cytometry[Baseline and 24 hours post-treatment];Changes in heart rate variability, assessed using standard power spectral analysis approaches[Baseline and 24 hours post-treatment]

Secondary Outcome Measures

Name	Time	Method
Changes in the size and activation state of leukocyte populations, as determined using flow cytometry[Baseline and 24 hours post-treatment];Changes in apoptosis of peripheral leukocytes, as determined by flow cytometry[Baseline and 24 hours post-treatment]