Improved Breast MRI With SWIFT

Not Applicable

Completed

Brief Summary: Today's medical imaging methods have insufficient specificity for reliable differentiation between benign and malignant breast lesions in patients. Pathologic evaluation is currently the only way to obtain a definitive diagnosis. This research will use a novel method of magnetic resonance imaging (MRI), Sweep Imaging with Fourier Transform (SWIFT), at a very high magnetic field (4 Tesla) to distinguish malignant from benign breast lesions. This research will reveal whether the SWIFT sequence bears new capabilities in medical imaging for breast cancer diagnosis.

Detailed Description: Patients will be asked to come to the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota. Researchers will interview the patient and describe procedures and risks. An intravenous (IV) line will be placed in an upper extremity for infusing magnetic resonance imaging (MRI) contrast dye. Baseline MRI scans will be done. These MRI measurements will be compared with clinical, radiological and pathological findings (the gold standard).

Follow-up contact will occur within one year after the MRI to determine whether a pathology report is available.

Recruitment & Eligibility

Inclusion Criteria

Women with a clinically or mammographically identified suspicious breast mass that is likely to be biopsied or surgically removed.

Exclusion Criteria

Pregnancy
Ferromagnetic implants
History of shotgun wounds and shrapnel
Obesity (>250 pounds)
Cardiac pacemaker
Incompatible implanted medical device
Severe claustrophobia
Major surgeries with potential of ferromagnetic implants
Severe asthma and allergies
i-STAT system, a handheld blood analyzer (I-STAT) creatinine test, estimated glomerular filtration rate (GFR) <30
Metallic object (greater than 2 cm in length) in the breast
Metallic ink tatoo within 20 cm of the breast (approximately 8 inches)

Arm && Interventions

Group	Intervention	Description
Healthy Volunteers	Magnetic resonance imaging	Five healthy women will be screened for Magnetic Resonance Imaging (MRI) contraindications, and then undergo contrast injection, and SWIFT acquisition.
Breast Cancer Patients	Magnetic resonance imaging	40 breast cancer patients who have suspected breast lesion that will be biopsied will be screened for Magnetic Resonance Imaging (MRI) contraindications, and then undergo contrast injection and SWIFT acquisition.

Primary Outcome Measures