study to see the effect of post operative systemic anticoagulation in patients undergoing post traumatic medium sized vessel repair.

Phase 3

Not yet recruiting

• Conditions: Injury of brachial artery,

• Registration Number: CTRI/2025/02/079981
• Lead Sponsor: Aiims

Brief Summary

Those Patients Who Will be Operated for definitive arterial repair will be included in the study considering in lusion and exclusion criteria, informed consent will be obtained, patient will be randomised in two groups, both groups will receive intra-op bolus heparin 80IU/KG Body weight. In post op period, group A will receive maintenance i.v heparin 18 IU/KG For 3 days while group B will not receive any systemic Anticoagulation in post op period.colour Doppler will be scheduled at post op day 2 and 5 OR Earlier in case of absent peripheral pulse in operated limb.

Outcome measures: patency of the repaired artery as measured by Doppler Study at an interval of 48 hours and 5th post op day or at the time of discharge  whichever is later.

Signs of bleeding requiring re-exploration or blood products transfusion.

Re-exploration will be decided after consultation with treating faculty.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-01-30
• Study Start: 2025-10-02

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 205

Inclusion Criteria

Patients with medium size vessel injury(4-8mm) includes Axillary artery, Brachial Artery,Femoral artery and Popliteal artery.

Exclusion Criteria

• Patients with head injuries.
• Pregnant Females.
• Patients already on Anticoagulation.
• Venous/Prosthetic graft repair.
• Contraindication of Anticoagulation due to associated injuries/Co-morbidities including CAD, Ischaemic heart disease, Stroke, Coagulopathies etc.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the effect of post operative systemic anticoagulation in terms of patency of medium size peripheral arterial repair in a vascular trauma	To assess the effect of post operative systemic anticoagulation in terms of patency of medium size peripheral arterial repair in a vascular trauma on post operative day 02 and just bedore discharge or on day 05 whichever is later

Secondary Outcome Measures

Name	Time	Method
To assess complications like	Post operative bleeding

Trial Locations

Locations (1)

Jai Prakash Narayan Apex Trauma Center, Aiims; 🇮🇳 Central, DELHI, India

Jai Prakash Narayan Apex Trauma Center, Aiims

🇮🇳Central, DELHI, India

Dr Ram Krishna Kumar

Principal investigator

7992208030

rkk14519891@gmail.com