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The influence of musculoskeletal physiotherapy on the immune response in patients with neck pain. - project MoTIO
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 140
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Persistent non-specific neck pain (research question (1)(2)(3))
- •* Age between 18-65 years.
- •* Minimal score of 4 on the Numeric Pain Rating Scale.
- •* Persistent pain is defined as pain complaints longer than 6 weeks.
- •* Can be classified as grade 1 or 2 non-specific neck pain.
- •* By physical examination a range of motion deficiency on the cervico-thoracic junction and a cervical segment.
- •* Written informed consent of the subject.;Cervical radiculopathy (research question (1)(3))
- •* Age between 18-65 years.
- •* Minimal score of 4 on the Numeric Pain Rating Scale.
- •* Pain should be present for a minimal of six weeks.
- •* Cervical radiculopathy based on the clinical diagnosis confirmed by the Magnetic Resonance Imaging (MRI through a medical specialist). The compression must be caused by a discus protrusion or herniation.
- •* Written informed consent of the subject. ;Healthy control group (research question (1))
- •* Age between 18-65 years.
- •* Asymptomatic for neck or shoulder pain and other musculoskeletal conditions in the past 3 months.
- •* Written informed consent of the subject.
排除标准
- •Persistent non-specific neck pain (research question (1)(2)(3));A potential subject who meets any of the following criteria will be excluded from participation in this study:
- •* Pregnancy or postpartum for 9 months
- •* Contra-indications for phlebotomy (e.g. phlebitis)
- •* Underwent treatment for current complaints for the last 6 weeks (e.g. physiotherapy, manual therapy, GP etc.)
- •* Having mental health disorders (> 74 points on the MHI-5)
- •* Taken one of the following medication for the last 6 weeks: corticosteroids (e.g. prednisone), immunomodulatory medication (e.g. methotrexate, infliximab etc.) and the use of botox for the last 3 months.
- •* Taken one of the following medication: NSAID*s (e.g. diclofenac, ibuprofen, naproxen etc.), Aspirin, Simvastatin for the last two weeks.
- •* Jet lag (within 7 days), ongoing shift work and hippocampal damage.
- •* Having one of the following medical diseases
- •o Neurological disorders (e.g. MS, myelopathie, cervical stenosis etc.)
- •o Traumatic disorders (e.g. cervical fracture, surgery in the neck area etc.)
- •o Having a history of malignity
- •o Rheumatic or inflammatory disorders (e.g. Spondylitis Ankylpoetica, Crohn disease, sarcoidosis, colitis ulcerous, rheumatic arthritis, COPD, spastic colon, psoriasis etc.)
- •o Cardiac diseases (e.g. history of myocardial infarction, abnormal heart rhythms)
- •o Allergic reaction or auto immune diseases (e.g. type 1 diabetic, hay fever)
- •o Metabolic disorders (e.g. type 2 diabetic)
- •o Endocrinology disorders (e.g. Cushing Syndrome)
- •o Haematological disorders (e.g. clothing problem)
- •o Psychological/psychiatric disorders (e.g. depression, current high stress, , Alzheimer disease)
- •o Physical trauma for the last six weeks
- •o Having the flue;Cervical radiculopathy (research question (1)(3))
- •A potential subject who meets any of the following criteria will be excluded from participation in this study:
- •* Pregnancy or postpartum for 9 months
- •* Contra-indications for phlebotomy (e.g. phlebitis)
- •* Underwent treatment for current complaints for the last 6 weeks (e.g. physiotherapy, manual therapy, GP etc.)
- •* Having mental health disorders (> 74 points on the MHI-5)
- •* Taken one of the following medication for the last 6 weeks: corticosteroids (e.g. prednisone), immunomodulatory medication (e.g. methotrexate, infliximab etc.) and the use of botox for the last 3 months.
- •* Taken one of the following medication: NSAID*s (e.g. diclofenac, ibuprofen, naproxen etc.), Aspirin, Simvastatin for the last two weeks.
- •* Having one of the following medical diseases
- •o Neurological disorders (e.g. MS, myelopathie, cervical stenosis etc.)
- •o Traumatic disorders (e.g. cervical fracture, surgery in the neck area etc.)
- •o Having a history of malignity
- •o Rheumatic or inflammatory disorders (e.g. Spondylitis Ankylpoetica, Crohn disease, sarcoidosis, colitis ulcerous, rheumatic arthritis, COPD, spastic colon, psoriasis etc.)
- •o Cardiac diseases (e.g. history of myocardial infarction, abnormal heart rhythms)
- •o Allergic reaction or auto immune diseases (e.g. type 1 diabetic, hay fever)
- •o Metabolic disorders (e.g. type 2 diabetic)
- •o Endocrinology disorders (e.g. Cushing Syndrome)
- •o Haematological disorders (e.g. clothing problem)
- •o Psychological/psychiatric disorders (e.g. depression, current high stress, Alzheimer disease)
- •o Physical trauma for the last six weeks <br
研究者
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