Investigation of dermal metabolism in burned and unburned human skin using the microdialysis method to quantify peripheral resuscitation following burn injury

Not Applicable

Completed

• Conditions: Burn injury; Injury, Occupational Diseases, Poisoning; Burns

• Registration Number: ISRCTN21069375
• Lead Sponsor: Record Provided by the NHSTCT Register - 2006 Update - Department of Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-09-29
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Study 1:
1.1. Potential healthy volunteers will be sought amongst colleagues and contacts locally. The reasons for the study and the procedure will be explained, but only those who show an interest and are keen to be involved will be recruited. No pressure will be put on anyone to volunteer. Appropriate volunteers will be given an information pack, and if they agree to go ahead, will be asked to sign a consent form. Should there be a large response, volunteers will be drawn at random after being grouped by age and sex.
1.2. Aged between 18 - 80 years (the burn population at Selly Oak does not include children. Persons over the age of 80 years are likely to have substantial co-morbidity, and have an extremely poor survival rate in large burns)

Study 2:
2.1. Once the study is commenced, consecutive patients who are to be admitted to Selly Oak Hospital Burns Unit with small burns and fitting the inclusion criteria will be invited to join the study. Clinical staff will be made aware of the study, and will alert the investigator when a suitable patient is admitted. The investigator will approach the patient to explain the study. An information leaflet will be given to the patient. Should they agree to involvement they will be asked to sign consent.
2.2. Aged between 18 - 80 years
2.3. Admission to Selly Oak Hospital (Selly Oak Hospital is the regional Burns Unit, so all burns in the region will come through this hospital)
2.4. Burns < 15% (these patients do not require formal resuscitation and will be unlikely to have a systemic inflammatory response associated with their injury)

Study 3:
3.1. All patients admitted to Selly Oak Hospital Burns Unit or Critical Care Unit with major burns will be highlighted to the investigator by clinical staff. Patients will be approached as soon as possible after admission and invited to join the study. The information leaflet will be explained to the patient and they will be invited to sign the consent form.
3.2. Aged between 18 - 80 years
3.3. Admission to Selly Oak Hospital
3.4. Burns greater than 30% (These patients will all be formally resuscitated. They will also have a systemic inflammatory response.)

Exclusion Criteria

Study 1:
1.1. Pre-existing skin or other medical conditions (these may interfere with the assessment of normal values)
1.2. Alcohol intake in past 6 hours (alcohol may affect metabolism)

Study 2:
2.1. Pre-existing skin or other medical conditions
2.2. Coexisting trauma (trauma can exacerbate the inflammatory response leading to a false reading)
2.3. Alcohol intake in past 6 hours

Study 3:
3.1. Pre-existing skin or other medical conditions
3.2. Coexisting trauma
3.3. Alcohol intake in past 6 hours

Study & Design

• Study Type: Interventional
• Study Design: Not specified