Correlating the Measure of Retinal Vascular Density Through Angio-OCT with Calcium Score

Not Applicable

Completed

• Conditions: Vascular Diseases; Cardiovascular Abnormalities; Retinal Vascular
• Interventions: Other: Ophthalmologic consultation

• Registration Number: NCT05624255
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

Recent case-control studies have proven that the retinal vascularization mirrors the cardiac vascularization: more the coronary network is altered, more the density of retinal vessels is reduced. No studies have yet been realised in primary prevention. This study aims to demonstrate a link between the density of the retinal vascularization and the calcium score, which is currently the gold standard for the classification of cardiovascular risk in primary prevention. Thus, a simple image of the retinal vascularization could predict the cardiovascular risk of a patient. OCT angiography would become a major aid in the classification of cardiovascular risk in asymptomatic patients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-11-14
• Study First Submitted QC: 2022-11-14
• Study First Posted: 2022-11-22
• Study Start: 2022-12-15
• Primary Completion: 2023-03-16
• Study Completion: 2023-03-16
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-14
• Last Update Posted: 2024-11-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 101

Inclusion Criteria

• Patients eligible for a calcium score as part of their standard treatment and volunteers for an ophthalmologic consultation

Exclusion Criteria

• Pregnant women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
ophthalmology consultation	Ophthalmologic consultation	Patients eligible to calcium score will be offered an ophthalmologic consultation including Angio-Optical Coherence Tomography \[OCT\]

Primary Outcome Measures

Name	Time	Method
Correlation between retinal vascular density and calcium score	Day 1	Comparison between values of calcium score and presence of vascular abnormalities in retina.; Calcium is scored as follows: * Coronary Artery Calcium \[CAC\] = 0 : very low risk; * CAC = \[1-100\[ : low risk; * CAC = \[100-400\[ : moderate risque; * CAC = \[400-1000\[ : high risk; * CAC = \> 1000 : very high risk

Trial Locations

Locations (1)

CHU de Besançon; 🇫🇷 Besançon, France