2024-518557-42-00招募中4 期
Endocrine, Cardiovascular, Pharmacological, and Physiological Aspects of Sex Hormone Therapy in Turner Syndrome - Study 1
Region Midtjylland1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2024年10月23日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Equipotency: Levels of luthenizing hormone and follicle stimulating hormone are measured at different doses
研究概览
简要总结
To determine the equipotency of two different estradiol regimens (oral versus transdermal administration) using various estradiol-dependent surrogate markers
入排标准
- 年龄范围
- 18 years 至 64 years（18-64 Years）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of Turner syndrome regardless of karyotype (Turner syndrome)
- •Age 18-50 years (Turner syndrome and healthy controls)
- •Already receiving estrogen treatment (Turner syndrome)
- •Female (healthy controls)
- •Previously healthy (healthy controls)
- •Not receiving any medication (healthy controls)
- •Not using any kind of contraceptive pills (healthy controls)
- •No mental or psychiatric disorders (healthy controls)
排除标准
- •Active systemic chronic diseases
- •Known or suspected breast cancer
- •Known or suspected estradiol-dependent tumors (endometrial cancer or similar)
- •Untreated endometrial hyperplasia
- •Current or previous venous thromboembolism
- •Acute or previous liver disease where liver enzymes are still elevated by a factor 3 or more
- •Known hypersensitivity to the medications used
- •Menopause (healthy controls only)
结局指标
主要结局
Equipotency: Levels of luthenizing hormone and follicle stimulating hormone are measured at different doses
Equipotency: Levels of luthenizing hormone and follicle stimulating hormone are measured at different doses
次要结局
未报告次要终点
研究者
Department of Endocrinology, Aarhus University Hospital
Scientific
Region Midtjylland
研究点 (1)
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