Latent Tuberculosis Infection in Renal Transplant Recipients
- Conditions
- Renal Transplant
- Registration Number
- NCT00682045
- Lead Sponsor
- Asan Medical Center
- Brief Summary
The aim of this study is to estimate the usefulness of a T cell-based assay (i.e. T-SPOT.TB assay) for diagnosis of latent tuberculosis infection (LTBI) in renal transplant recipients. For this purpose, the investigators enrolled renal transplant recipients and observed the developement of tuberculosis within 1 to 2 years after the transplantation.
- Detailed Description
We evaluate the usefulness of a newly-developed T cell-based assay prior to undergoing immunosuppression in renal transplant recipients. Among all renal transplant recipients, patients with negative tuberculin skin test and no other indications for latent tuberculosis infection will be enrolled in this study. We will exam T-SPOT.TB test in these patients, and observe the developement of tuberculosis within 1 to 2 years after the transplantation. The results of T-SPOT.TB will be blinded to the investigators.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 240
- Age 16 or more
- Negative tuberculin skin test (induration less than 10 mm)
- Recent contact of patients with active pulmonary tuberculosis
- Suspected active tuberculosis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method development of tuberculosis within 2 years after transplantation
- Secondary Outcome Measures
Name Time Method all cause mortality within 2 years after transplantation
Trial Locations
- Locations (1)
Asan Medical Center
🇰🇷Seoul, Korea, Republic of