A Prospective Observational Study of Usefulness of a T Cell-based Assay for Latent Tuberculosis Infection in Hematopoietic Stem Cell Transplant Recipients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 409
- 试验地点
- 1
- 主要终点
- development of tuberculosis
研究概览
简要总结
The aim of this study is to estimate the usefulness of a T cell-based assay (i.e. Quantiferon-Gold In-Tube assay) for diagnosis of latent tuberculosis infection (LTBI) in bone marrow transplant recipients. For this purpose, the investigators enrolled bone marrow transplant recipients and observed the developement of tuberculosis after the transplantation.
详细描述
All adult bone marrow transplant recipients admitted to Asan Medical Center will be enrolled.
Quantiferon-Gold In-Tube assay will be performed.
Isoniazid prophylaxis will be given only to patients with clinical risk factors (i.e. recent contact with active pulmonary TB patient or inadequate treatment history with abnormal CXR). However, isoniazid prophylaxis will be not given based on positive TST or positive Quantiferon-Gold In-Tube assay.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 16 or more
- •Bone marrow transplant recipients
排除标准
- •Recent contact of patients with active pulmonary tuberculosis
- •Suspected active tuberculosis
结局指标
主要结局
development of tuberculosis
时间窗: after transplantation
次要结局
- all cause mortality(after transplantation)
研究者
Sung-Han Kim
Assistant Professor
Asan Medical Center