Determination of the Mechanisms Involved in Conduit Artery Endothelial Dysfunction in Type 2 Diabetes

University Hospital, Rouen1 site in 1 country48 target enrollmentDecember 2014

ConditionsDiabetes Mellitus, Type 2

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Diabetes Mellitus, Type 2
Sponsor: University Hospital, Rouen
Enrollment: 48
Locations: 1
Primary Endpoint: Change from Baseline in EET concentration during endothelial stimulation
Status: Completed
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Endothelial dysfunction of conduit arteries plays an important role in the development of cardiovascular complications associated with type 2 diabetes. In order to propose targeted therapeutic approaches, this study aim to determine the mechanisms involved in endothelial dysfunction of conduit arteries in these patients.

Registry

clinicaltrials.gov

Start Date

December 2014

End Date

December 2016

Last Updated

8 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University Hospital, Rouen

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Type 2 diabetic patients or control subjects or healthy volunteers

Exclusion Criteria

•Macroangiopathy
•Insulin treatment
•Chronic kidney disease (eGFR\<60 ml/min/m²)
•Hyperlipidemia (total cholesterol\>2.5 g/l)
•Smoking habit \> 5 cigarettes/day
•Pregnancy

Outcomes

Primary Outcomes

Change from Baseline in EET concentration during endothelial stimulation

Time Frame: 30 min from the beginning of hand skin heating

Secondary Outcomes

Change from Baseline in NO concentration during endothelial stimulation(30 min from the beginning of hand skin heating)
Change from Baseline in ET-1 concentration during endothelial stimulation(30 min from the beginning of hand skin heating)
Change from Baseline in ROS concentration during endothelial stimulation(30 min from the beginning of hand skin heating)