NCT02783716
Terminated
Not Applicable
Vascular Endothelial Function and Cardiac Resynchronization Response in Patients With Heart Failure
ConditionsHeart Failure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- Mayo Clinic
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Change in vascular endothelial function
- Status
- Terminated
- Last Updated
- 3 years ago
Overview
Brief Summary
The purpose of this research study is to determine the role of blood vessel endothelial function in heart failure and the effect of Cardiac Resynchronization Therapy (CRT) on heart and endothelial function.
Investigators
Hon-Chi Lee, M.D., Ph.D.
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •CRT Group: Patients recommended for CRT-P or CRT-D for heart failure (HF) according to current American Heart Association (AHA)/American College of Cardiology (ACC)/Heart Rhythm Society (HRS) guidelines of Left Ventricle Ejection Fraction (LVEF)\<35%, Left Bundle Branch Block (LBBB)\>120 ms, New York Heart Association (NYHA) Class II-III).
- •Control Group: Patients who undergo device (pacemaker or ICD) implantation or a pack change for sinus node dysfunction or AV blocks
Exclusion Criteria
- •Patients who are unwilling or unable to return for follow up visits 3 months after device implantation.
Outcomes
Primary Outcomes
Change in vascular endothelial function
Time Frame: baseline, 3 months
Vascular endothelial function will be measured using peripheral arterial tonometry as the reactive hyperemia index (RHI) at baseline and at 3 months.
Study Sites (1)
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