The Impact of Platelet Functions on Spontaneous Ductal Closure in Preterm Infants
- Conditions
- Patent Ductus Arterioses
- Registration Number
- NCT02010879
- Lead Sponsor
- Ankara University
- Brief Summary
Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses, there is lack of data on the function of platelets in ductal closure. Information on functions of platelets in ductal closure may change the known model for ductus arterioses and may affect the treatment modalities.
- Detailed Description
Patent ductus arterioses is a common problem which involves both pulmonary and cardiac outcomes in preterm infants. Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses, there is lack of data on the function of platelets in ductal closure.
The investigators aim to investigate the relation between thrombocytopenia and platelet functions in pathogenesis of spontaneous ductal closure. The investigators hypothesize that Information on functions of platelets in ductal closure may change the known model for ductus arterioses and may affect the treatment modalities.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 80
- gestational age lower than 30 weeks and birth weight lower than 1500 g
- obtained informed consent
- any received medical treatment in first 2 days of life
- death in first 2 days
- patients who received any thrombocyte or fresh frozen plasma suspensions
- any known genetic thrombocyte disorder in the family
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method spontaneous ductal closure 8 weeks ductal closure confirmed by echocardiography on postnatal 2-3 days
- Secondary Outcome Measures
Name Time Method need for treatment 8 weeks any need for medical treatment (ibuprofen or paracetamol) or surgical treatment
Trial Locations
- Locations (1)
Ankara University Children's Hospital
🇹🇷Ankara, Turkey