Analysis of Proteome and Pathophysiological Characteristics of Human Blood Cells
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Blood examination
研究概览
简要总结
The aim of this study is to investigate wether change in endothelial nitric oxid synthase of blood cells (erythrocytes and peripheral blood mononuclear cells (PBMC)) has an influence on development and progression of cardiovascular diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers
- •Patients: stable coronary artery disease with accordingly endothelial dysfunction
排除标准
- •acute inflammation (CRP>0,5 mg/dl, leucocyte >11000/dl)
- •malignant diseases
- •acute or terminated kidney disease
- •relevant heart failure (NYHA III-IV)
结局指标
主要结局
Blood examination
时间窗: baseline
Following parameters will be examined: * Blood count (red cells, white cells, platelets, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), mean platelet volume (MPV) ) * Creatinin * Urea * Glucose * Glycated hemoglobin (HbA1c) * Cholesterol * Triglyceride * C-reactive Protein * Apolipoprotein
次要结局
- Protein expression(baseline)
- Nitric oxid metabolite and proteins in blood plasma, red blood cells and peripheral blood mononuclear cells (PBMN)(baseline)
- Asymmetric dimethylarginine (ADMA) and Cytokine(baseline)
- Microparticles(baseline)
- Nitric oxid and reactive oxygen species(baseline)
- Immunocytochemistry(baseline)
研究者
Klinik für Kardiologie, Pneumologie und Angiologie
Principle Investigator Prof. Dr. Malte Kelm
Heinrich-Heine University, Duesseldorf