Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis

Withdrawn

• Conditions: Colitis; Colon Cancer

• Registration Number: NCT03014284
• Lead Sponsor: The University of Texas Health Science Center at San Antonio

Brief Summary

This is a simple tissue collection study with no therapeutic intent. Colon tissues will be taken from standard of care procedures. Tissues will be tested for their functions, expression of immune co-signaling molecules and reactions to transduction with recombinant Listeria vectors to assess effects on expression of B7-H1 and cytokines.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-12-20
• Study First Submitted QC: 2017-01-06
• Study First Posted: 2017-01-09
• Study Start: 2017-01-20
• Status Verified: 2018-02
• Primary Completion: 2018-09-12
• Study Completion: 2018-09-12
• Last Update Submitted: 2018-09-13
• Last Update Posted: 2018-09-17

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Able to provide informed consent (or have consent provided through a guardian)
• No immune-modulating drug use during study or within 30 days prior to enrollment
• Having colon material collected as part of standard of care

Exclusion Criteria

• Unable to provide informed consent (or have consent provided through a guardian)
• Not having colon material collected as part of standard of care

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Expression of B7-H1	Baseline tissue collection	To assess the ability of recombinant Listeria to modulate B7-H1 in human colonic tissues

Trial Locations

Locations (1)

Cancer Therapy & Research Center at UTHSCSA; 🇺🇸 San Antonio, Texas, United States