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Clinical Trials/NCT04176783
NCT04176783
Completed
Not Applicable

Carolina's Opioid Reduction Effort

OrthoCarolina Research Institute, Inc.1 site in 1 country511 target enrollmentMarch 26, 2018

Overview

Phase
Not Applicable
Intervention
Opioids
Conditions
Pain Management
Sponsor
OrthoCarolina Research Institute, Inc.
Enrollment
511
Locations
1
Primary Endpoint
Pain at 24 hours postop
Status
Completed
Last Updated
last year

Overview

Brief Summary

To compare the safety and effectiveness of two pain control pathways following routine orthopaedic surgical procedures (single level or two-level ACDF/ACDA, 1st CMC arthroplasty, Hallux Valgus/Rigidus corrections, diagnostic knee arthroscopies, total hip arthroplasty, and total shoulder arthroplasty / reverse total shoulder arthroplasty). The control group will undergo surgery with an opioid-based pain protocol and the intervention group will undergo surgery with a multimodal, opioid-free protocol.

Patients will have data collected with respect to pain scores, overall comfort level, overall satisfaction with the surgical experience and recovery, constipation, falls, and overall satisfaction with pain control, in addition to procedure-specific outcome scores and patient-specific metrics.

Registry
clinicaltrials.gov
Start Date
March 26, 2018
End Date
December 31, 2024
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Not provided

Arms & Interventions

Opioid

The opioid-based arm utilizes traditional, standard-of-care treatment for each applicable surgery. The medications (including dosage and frequency) used in this arm vary depending on the surgery being performed; however, tend to include medications in the opioid family such as Hydromorphone, Hydrocodone, Tramadol, or Oxycodone.

Intervention: Opioids

Opioid-Free

The opioid-free arm utilizes medications that do not belong to the opioid family of medications. All medications used are FDA-approved and no experimental medications are being used. The medications (including dosage and frequency) used in this arm vary depending on the surgery being performed; however, tend to include medications such as Gabapentin, Tylenol, Meloxicam, Bupivacaine, or Ketorolac.

Intervention: Opioid-Free

Outcomes

Primary Outcomes

Pain at 24 hours postop

Time Frame: 24 hours

Numeric Pain Rating Scale 0-10, with 10 representing the highest/worst pain score

Secondary Outcomes

  • Pain at 1 year postop(1 year)
  • General Health(1 year)
  • Pain at 12 hours postop(12 hours)
  • Pain at 2 weeks postop(2 weeks)
  • Pain at 6 weeks postop(6 weeks)
  • Pain at 6 hours postop(6 hours)

Study Sites (1)

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