Effect of ESPB on Intraoperative Remifentanil Consumption

Not Applicable

Recruiting

• Conditions: Lumbar Spine Surgery; Erector Spinae Plane Block; Remifentanil Consumption
• Interventions: Drug: Preoperative Erector Spinae Plane Block; Drug: Postoperative Erector Spinae Plane Block

• Registration Number: NCT06303557
• Lead Sponsor: Atatürk Chest Diseases and Chest Surgery Training and Research Hospital

Brief Summary

In recent years, regional anesthesia techniques have also been frequently applied to patients for pain relief. Erector spinae plane block (ESPB), is among the regional anesthesia techniques frequently used in lumbar spine surgery.

General anesthesia (GA) is the main method of anesthesia for lumbar spine surgery. However, GA can only inhibit the projection system of the cortical limbic system or hypothalamic cortex. GA cannot completely block the transmission of peripheral noxious stimulus to the central nervous system and cannot effectively inhibit the intraoperative stress response. With the addition of peripheral blocks such as ESPB, lower remifentanil consumption, and more stable hemodynamics are expected by providing preemptive analgesia in patients.

As a result of all these; it was aimed to compare the intraoperative remifentanil consumption of patients who underwent preoperative ESPB in patients who will undergo lumbar spine surgery resection under GA with those who underwent postoperative ESPB.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-31
• Study First Submitted: 2024-02-26
• Study First Submitted QC: 2024-03-04
• Study First Posted: 2024-03-12
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-02
• Last Update Posted: 2024-05-03
• Primary Completion: 2024-11-30
• Study Completion: 2024-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 18 to 65 years old
• American Society of Anesthesiologists (ASA) physical status I-II-III
• Body mass index 18 to 40 kg/m2
• Elective lumbar disc herniation surgery

Exclusion Criteria

• Patient refusing the procedure
• Patients who have previously undergone spinal surgery
• Chronic opioid or analgesic use
• Patients who will operate under emergency conditions
• Patients who will not undergo lumbar disc herniation surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Preoperative Erector Spinae Plane Block	Preoperative Erector Spinae Plane Block	In the preoperative period, under general anesthesia, after the linear ultrasound (US) probe will be placed 2-3 cm lateral to the L3 spinous process, 15 ml of 0.25% bupivacaine will be injected into the interfacial space below the erector spinae muscle, above the transverse process. The same ESPB procedure was performed on the other side. In total, 40 ml of 0.25% bupivacaine was administered.
Postoperative Erector Spinae Plane Block	Postoperative Erector Spinae Plane Block	In the postoperative period, under general anesthesia, after the linear ultrasound (US) probe will be placed 2-3 cm lateral to the L3 spinous process, 15 ml of 0.25% bupivacaine will be injected into the interfacial space below the erector spinae muscle, above the transverse process. The same ESPB procedure was performed on the other side. In total, 40 ml of 0.25% bupivacaine was administered.

Primary Outcome Measures

Name	Time	Method
Intraoperative remifentanil consumption	During the intraoperative period	The amount of remifentanil that patients need to maintain anesthesia during the intraoperative period will be recorded.

Secondary Outcome Measures

Name	Time	Method
Mean arterial pressure	Perioperative period	Mean arterial pressure values will be recorded before anesthesia, before surgical incision, after surgical incision at the 5th, 30th, 60th, 90th, 120th minutes, and after general anesthesia.
Heart rate	Perioperative period	Heart rate values will be recorded before anesthesia, before surgical incision, after surgical incision at the 5th, 30th, 60th, 90th, 120th minutes, and after general anesthesia.
Pain scores	First 24 hours after surgery	Pain will be assessed at rest and while coughing using the visual analog scale on a scale from 0 (no pain) to 10 (worst pain). Pain assessment will be done at the 1st, 2nd, 6th, 12th, and 24th hours after surgery.

Trial Locations

Locations (1)

Ankara Etlik City Hospital; 🇹🇷 Yenimahalle, Ankara, Turkey