Impact of Chronic Rhinosinusitis on the Index of Ciliary Beat Efficiency Using Fluorescent Nanosticks
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 94
- 试验地点
- 2
- 主要终点
- The shear stresss by tracking nano-batons (mPa)
研究概览
简要总结
Impact of chronic rhinosinusitis on the index of ciliary beat efficiency using fluorescent nanosticks
详细描述
To date, the assessment of ciliary beat is only possible ex vivo on epithelial cells obtained from upper airway brushing. A previous prospective study (I-IsBac) showed a change in ciliary beat (in terms of coordination and frequency) in bacterial rhinosinusitis. The study of ex-vivo ciliary movement appears to be an interesting tool to understand the pathophysiology of CSRs and to guide and evaluate treatment.
A new tool to evaluate the effectiveness of the ex-vivo lash beat has been developed. This tool measures shear stress by tracking balls along the ciliary margin.
This measurement of ex-vivo shear stress by bead tracking is a validated technique. However, microbead tracking is limited by its low spatial and temporal resolution, long measurement time and heavy post-processing of acquisition data, making this method difficult to use in clinical routine. Monitoring ex-vivo fluorescent nano-batons could represent a simpler alternative for the clinician. This measurement is now made possible by Phosphate Lanthanum Lanthanum Nano-batons (LaPO4) whose luminescence is directly proportional to the shear.
The objective of this research project is to validate this new tool in patients with CSR by comparing it to a group of control subjects free of nasal inflammation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient ≥ 18 years old
- •Having chronic rhinosinusitis (RCS) requiring surgical treatment. Or
- •With an indication for endonasal surgery for nasal obstruction (turbinoplasty and septoplasty) or for an endonasal surgical approach
- •Acceptance to participate in the protocol with signed informed consent
- •Affiliated or beneficiary of a social security scheme
排除标准
- •Refusal to participate in the study
- •No one who does not speak or understand French
- •Pregnant or breastfeeding woman
- •Persons who are incapable of reaching the age of majority, under guardianship, guardianship or protection of justice.
- •Simulated participation in another intervention research
研究组 & 干预措施
Patient with Chronic Rhinosinusitis (CRS)
Patients with endonasal surgery scheduled under general anesthesia for an indication of Chronic Rhinosinusitis (CRS)
干预措施: nasal brushing and bacteriological sample (Procedure)
Patient without Chronic Rhinosinusitis (CRS)
Patients with endonasal surgery scheduled under general anesthesia for an indication of endonasal surgery for nasal obstruction or patients requiring an endonasal surgical approach such as pituitary adenomas for example.
干预措施: nasal brushing and bacteriological sample (Procedure)
结局指标
主要结局
The shear stresss by tracking nano-batons (mPa)
时间窗: Day of the surgical procedure under General Anesthesia
The value of the shear stress by tracking nano-batons in mPa
次要结局
- Mucosal inflammation score (0 to 10)(Inclusion Visit)
- Presence of pus at endoscopy(Inclusion Visit)
- Frequency of ciliary beat(Day of the surgical procedure under General Anesthesia)
- Shear stress by Tracking microbeads (mPa)(Day of the surgical procedure under General Anesthesia)
- Presence of polyps at endoscopy(Inclusion Visit)
- coordination of cillary beat(Day of the surgical procedure under General Anesthesia)