The use of the oral antibiotic, roxithromycin, prior to endoscopic surgery of the paranasal sinuses, to improve the surgical field and outcomes
Phase 4
- Conditions
- Chronic rhinosinusitisOther - Conditions of unknown or disputed aetiology (such as chronic fatigue syndrome/myalgic encephalomyelitis)Inflammatory and Immune System - Other inflammatory or immune system disorders
- Registration Number
- ACTRN12611000485932
- Lead Sponsor
- Royal Victorian Eye and Ear Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 58
Inclusion Criteria
1. age above 18
2. able to give written informed consent
3. listed to undergo functional endoscopic sinus surgery (FESS) for chronic rhinosinusitis with or without nasal polyposis
Exclusion Criteria
1. those who have a history of hypersensitivity to roxithromycin (rulide)
2. those who are having endoscopic procedures for excision of malginant pathology
3. diabetics who are therefore unable to take a course of preoperative prednisilone
4. those whose comordities mitigate against taking peri-operative topical cocaine for decongestion
5. those who have hypersensitivity to co-phenylcaine forte
6. patients who have taken antibiotic therapy in the preceding 4 weeks
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method surgical field as graded by the Boezaart scale[Perioperative]
- Secondary Outcome Measures
Name Time Method SNOT 22 scores[2 week pre-operative, immediately prior to surgery, 2 week and 3 month post surgery];post-operative synechiae assessed subjectively by the examining ENT surgeon[2 weeks post-operative];nasal microbiological swab results[2 week pre-operative, during surgery, 2 week post-operative]