The Role of 18F-FDG-PET/CT Scan in Lung Cancer Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- PET/CT in lung cancer
研究概览
简要总结
Describe strengths and limitations of FDG PET/CT for staging. Evaluate the utility of PET/CT in assessment of therapy response and restaging
详细描述
Lung cancer is one of the most common cancers and it represents the main cause of cancer mortality worldwide.
It is histopathological classified into main groups: Small cell lung cancer (15%) and Non-small cell lung cancer (85%). NSCLCs are generally subcategorized into adenocarcinoma, squamous cell carcinoma (SqCC), and large cell carcinoma. Positron emission tomography (PET) is now an important cancer imaging tool, both for diagnosis and staging, as well as offering prognostic information based on response.
PET sets the gold standard in the evaluation of an indeterminate solitary pulmonary nodule or mass, where PET has proven to be significantly more accurate than computed tomography (CT).
For NSCLC chest CT is the standard imaging modality for assessing primary tumor size and identifying its margins. PET-CT may be helpful in assessing a nodule located in same lobe. It can also provide information on parietal or mediastinal involvement. PET is useful for differentiating tumor tissue from atelectasis, which may be helpful if radiotherapy is planned to determine the target volume .
In the evaluation of metastatic spread to loco-regional lymph nodes, PET is significantly more accurate than CT, so that invasive surgical staging may be omitted in many patients with negative mediastinal PET images.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with pathologically proven lung cancer and referred to nuclear medicine unit to perform PET/CT for staging and patient referred for assessment of response of therapy and re staging.
排除标准
- •Pregnant women.
- •Patients unable to sleep in a fixed position for 20 minutes.
- •Severely ill patients who aren't capable of complying with study procedures or comatose patients.
- •Patients with known second primary
结局指标
主要结局
PET/CT in lung cancer
时间窗: one year
* Analysis of the number and type of metastatic lesions detected by PET/CT in lung cancer patients(staging). * Analysis of the number and type of metastatic lesions detected by PET/CT in lung cancer patients after therapy(re staging).
次要结局
- PET/CT in lung cancer(one year)
研究者
Walaa Otify Thabet
Assistant Lecturer-principal investigator
Assiut University