Comparison of effect of pre-operative nebulisation with two different medicines in reducing post-operative sore throat

Not yet recruiting

Conditions: Chronic cholecystitis, (2) ICD-10 Condition: K402||Bilateral inguinal hernia, withoutobstruction or gangrene, (3) ICD-10 Condition: K409||Unilateral inguinal hernia, without obstruction or gangrene, (4) ICD-10 Condition: N979||Female infertility, unspecified, (5) ICD-10 Condition: N849||Polyp of female genital tract, unspecified, (6) ICD-10 Condition: N839||Noninflammatory disorder of ovary,fallopian tube and broad ligament, unspecified,

Registration Number: CTRI/2019/06/019540

Brief Summary: This is a prospective, randomised, double blinded, placebo controlled study to compare the efficacy of pre operative Dexmedetomidine and Ketamine nebulisation on reducing the incidence and severity of post operative sore throat. We hypothesize that Dexmedetomidine nebulisation will be more effective in reducing incidence and severity of post operative sore throat.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 132

Inclusion Criteria

ASA I&II patients undergoing laproscopic surgeries under general anaesthesia lasting up to two hours requiring endotracheal intubation.

Exclusion Criteria

Difficult laryngoscopy or more than 1 attempt at intubation,patients on steroid or NSAID,pre existing pharyngeal or laryngeal disease,upper airway surgeries,surgeries requiring insertion of throat pack intra operatively,more than one attempt to pass orogastric or nasogastric tube,patients refusing consent.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction in incidence and severity of post operative sore throat	2,6,12,24 hours post surgery

Secondary Outcome Measures

Name	Time	Method
Haemodynamic changes in the study group	During pre operative assessment,before induction of anaesthesia,post -laryngoscopy,at 15 minute interval intraoperatively,after shifting to post anesthesia care unit
Post operative analgesia among the study groups	2,6,12,24 hours after shifting to post anaesthesia care unit
Post operative sedation among the study groups	2,6,12,24 hours after shifting to post anaesthesia care unit
post operative nausea and vomiting among the study groups	2,6,12,24 hours after shifting to post anaesthesia care unit

Trial Locations

Locations (1): ALL INDIA INSTITUTE OF MEDICAL SCIENCES,RISHIKESH
🇮🇳
Dehradun, UTTARANCHAL, India
ALL INDIA INSTITUTE OF MEDICAL SCIENCES,RISHIKESH
🇮🇳Dehradun, UTTARANCHAL, India
AMANTA LUCY ITTOOP
Principal investigator
8289886858
lucyamanta@gmail.com