Evaluation of endometrium stimulation with estrogen gestagen post hysteroscopic adhesiolysis and long term outcomes
- Conditions
- Asherman Syndrome
- Registration Number
- NL-OMON24510
- Lead Sponsor
- o sponsor
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 110
Consented patients with Asherman Syndrome (AS) who had a successful hysteroscopic adhesiolysis, defined as a restore of the normal uterine cavity, were eligible for inclusion. Patients with AS should be defined as patients with any diminishing of blood flow (secondary amenorrhoea or secondary hypomenorrhoe) after trauma to the uterine cavity due to pregnancy related surgical procedure with the presence of intrauterine adhesions with a previous history of normal menstrual blood flow.
- Patients with a suspected AS due to tuberculosis or schitsosomiasis.
- Patients with an uncorrected anovulation, amenorrhoe or oligomenorrhoe previous to the AS
- Patients with suspected AS due to hysteroscopic surgery with the use of electrocoagulation (used in fibroid or polyp surgery)
- Patients with congenital uterine anomalies
- Patients with contraindications for a surgical adhesiolysis
- Patients who do not master the Dutch or English language.
- Patients who are younger than 18 years of age or mentally incompetent.
- Patients with contraindications for estrogen and or gestagen
-Patients who use hormonal suppletion
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Spontaneous recurrence of intra uterine adhesion
- Secondary Outcome Measures
Name Time Method <br>•Ongoing pregnancy (in those patients willingly to conceive) after one year follow-up. During a follow up of 1 year the number and time to conceive will be recorded. The clinical as well as the ongoing pregnancies (defined as intra-uterine heart activity at 12 weeks gestation) <br><br>•The number of performed re-interventions (hysteroscopic adhesiolysis in the OR or outpatient clinic or adhesiolysis without hysteroscopy (dilatation) in outpatient clinic setting) <br><br>•Complication related to postoperative estrogen and gestagen administration or any side-effect. <br><br>. Long term follow-up over 10 years, re-interventions, fertility outcome, pregnancy outcome, obstetrical outcome and chronicle pelvic pain