Photoprovocation Testing in Subjects With Cutaneous Lupus

Not Applicable

Completed

• Conditions: Lupus Erythematosus; Photosensitivity Conditions
• Interventions: Other: Phototesting

• Registration Number: NCT01516788
• Lead Sponsor: University of Pennsylvania

Brief Summary

Photosensitivity is well documented among lupus patients and is one of the diagnostic criteria for systemic lupus erythematosus (SLE). Photosensitivity is highly prevalent in lupus and has a wide range of clinical presentations. However, photosensitivity is a poorly defined in lupus and its pathogenesis is not well understood. The purpose of this study is to characterize the early clinical and histopathological changes in lupus skin that occur as a response to ultraviolet light.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2011-12
• Study First Submitted: 2012-01-12
• Study First Submitted QC: 2012-01-19
• Study First Posted: 2012-01-25
• Primary Completion: 2018-07-02
• Study Completion: 2018-07-02
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-12
• Last Update Posted: 2021-07-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

• Participants who have a diagnosis of CLE based on either the Gilliam classification of DLE and SCLE, or SLE based on the American College of Rheumatology criteria.

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Exclusion Criteria

1. Participants who do not meet criteria for either CLE or SLE.
2. Participants with a diagnosis of Erythropoietic Protoporphyria and Solar Urticaria, or another photodermatoses other than Polymorphous light eruption.
3. Participants who are not yet 18 years old or who are not capable of giving written informed consent prior to enrolling in the study.
4. Participants who have undergone any recent phototesting, or phototherapy exposure, or those who are suspected of having a drug-induced photosensitivity.
5. Female participants who are pregnant or breastfeeding will be excluded from the study. This will be determined by patient self-reporting.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Phototesting	Phototesting	-

Primary Outcome Measures

Name	Time	Method
The change from baseline of the neutrophil and inflammasome response to ultraviolet radiation at 24 hours.	24 hours and 48 hours

Trial Locations

Locations (1)

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States