NCT01777789
Terminated
Not Applicable
The Role of Mid-Life Adiposity in Functional Brain Connectivity
Medical College of Wisconsin1 site in 1 country60 target enrollmentStarted: December 2012Last updated:
ConditionsAlzheimer's Disease
Overview
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Medical College of Wisconsin
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Brain connectivity measured by fMRI
Overview
Brief Summary
The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat. The ultimate goal of this research is to develop an early diagnostic tool for Alzheimer's disease.
Detailed Description
Participants will have one visit for:
- Blood draw
- Body composition scan
- Cognitive screen
- Neurological exam
- MRI scan
The visit will take approximately 3 hours.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 45 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •45-65 years of age
- •Normal memory
- •Right-handed
- •General good physical health
Exclusion Criteria
- •History of stroke or neurological disease
- •Seizures or head injury with loss of consciousness within the last five years
- •Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner)
- •Claustrophobia
- •More detailed inclusion/exclusion criteria must be met in order to qualify for the study. The study coordinator will determine eligibility.
Outcomes
Primary Outcomes
Brain connectivity measured by fMRI
Time Frame: One visit
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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