Effects of Exercise Interventions in Frail Middle-aged and Older Adults
- Conditions
- Frailty
- Interventions
- Device: exercise training
- Registration Number
- NCT05279625
- Lead Sponsor
- Taipei Veterans General Hospital, Taiwan
- Brief Summary
This study aimed to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and mental functions.
- Detailed Description
Exercise has been suggested as a possible lifestyle intervention for improving physical and cognitive performance. Various training options depending on various physical circumstances will be presented. However, the ideal exercise protocol for frail middle-aged and older adults had the greater benefits remain unknown. In general, 3-6 months of frequent exercise can enhance physical and cognitive outcome.
The investigators conduct this multiple arm, prospective study to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and cognitive functions. This study designed to recruit 200 older adults with frailty. All the older adults will receive exercise training using either elastic band, dumbbells, machines, treadmill, cycling for 6 months. Outcome measures including a systematic evaluation for frail older persons using comprehensive geriatric assessment, as well as the assessments of physical and cognitive functions before and after interventions.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
- Patients aged above 50 years old with frailty syndrome
- Acute illnesses, such as unstable cardiac dysrhythmia, sepsis, or unstable vital signs
- Physical or Cognitive issues that make it difficult for the patients to participate in our program
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description traditional rehabilitation exercise training traditional rehabilitation for 6 months machine-assisted exercise training exercise training machine-assisted exercise training for 6 months Interval exercise training exercise training Interval exercise training using either elastic band, dumbbells, treadmill, cycling for 6 months continuous exercise training exercise training continuous exercise training using either elastic band, dumbbells, treadmill, cycling for 6 months
- Primary Outcome Measures
Name Time Method Change of Montreal Cognitive Assessment Up to 6 months Test cognition including memory, attention, and language, range from 0-30, higher values represent a greater outcome
Change of Geriatric Depression Scale Up to 6 months Test depression status, , range from 0-15, higher values represent a worse outcome
Change of Lawton Instrumental Activities of Daily Living (IADL) Scale Up to 6 months To assesses a person's ability to perform tasks such as using a telephone, doing laundry, and handling finances.y. A summary score ranges from 0 (low function, dependent) to 8 (high function, independent)
Change of Barthel index Up to 6 months Test function of activities of daily living, range from 0-100, higher values represent a greater outcome.
- Secondary Outcome Measures
Name Time Method Change of Digit symbol substitution test Up to 6 months Test cognitive function. The test consists of filling as many empty boxes as possible with a symbol matching each number. The score is the number of correct number-symbol matches achieved.
Change of Six-minute Walking Test Up to 6 months Test physical function. In healthy subjects, the 6-min walk distance ranges from 400 to 700 m.
Change of Timed Get-up-and-go Test Up to 6 months Test for quantifying functional mobility
Change of Memory span test Up to 6 months an examiner reads a list of random numbers aloud at about the rate of one number per second. At the end, the person being tested is asked to recall the items, in order.
Change of Mini-mental state examination Up to 6 months Test cognitive function, range from 0-30, higher values represent a greater outcome
Change of Color Trails Test Up to 6 months Test cognitive function. Test is scored by how long it takes to complete the test.
Trial Locations
- Locations (1)
Department of Physical Medicine & Rehabilitation, Taipei Veterans General Hospital, Yuan-Shan/Su-Ao Branch
🇨🇳Yilan, Taiwan