Effect of oral cranberry extract (standardised proanthocyanidin-A) on the uropathogenic bacteria in urine of patients with subclinical/recurrent UTI â?? A randomised placebo controlled clinical study.

niversity College of Medical Sciences0 个研究点目标入组 72 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1. Patients with subclinical (asymptomatic bacteriuria)and or recurrent UTI (three episodes of UTI in the last 12 months or two episodes in the last 6 months).
•2.Patients with UTI not responding to antimicrobial therapy due to any cause including multidrug resistance.
•3. Patients prone to recurrent UTIs [like geriatric women, geriatric men with symptomatic BPH, patients on clean intermittent catheterization (CIC), chronically catheterized patients (indwelling catheter, suprapubic catheter) patients with spinal cord injury/ stroke / paraplegia/ abnormalities of urinary tract].
•4.Patients with subclinical (asymptomatic)/recurrent UTI who are off any antibiotics for the past two weeks.
•The working definition of recurrent UTI used by us for this study was : Patients with recurrent UTI ( > 2 episodes) who had culture positive/sensitive UTI and had taken multiple courses of antimicrobials in the past one year or so and desiring alternative therapy were given the option of entering in to this randomized controlled clinical trial (Cranberry extract or lactobacillus capsules).

•1. Patients with the first episode of symptomatic active UTI (defined as >100000 bacteria/HPF in midstream urine culture).
•2.Pregnant and or lactating patients.
•3.Patients in the pediatric age group.
•4.Patients with known history of hypersensitivity to PAC-A /Cranberry extract.
•5. Patients with known history of hyperoxaluria/known renal oxalate stone formers.
•6. Patients not consenting for the study

发起方

niversity College of Medical Sciences