Characterization of the Temporal Profile of the Anti-nociceptive Effect of Ketamine Bolus Measured With ANI

Completed

• Conditions: Analgesia; Ketamine; Pharmacokinetic

• Registration Number: NCT06344858
• Lead Sponsor: Pontificia Universidad Catolica de Chile

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-2-5
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Inclusion Criteria:<br><br> - Elective surgery with general anaesthesia<br><br> - Without premedication<br><br> - ASA I, II or III<br><br>Exclusion Criteria:<br><br> - Body weight greater than 120% of ideal weight<br><br> - Ingestion of sedatives of short or long action in the 48 hours before surgery<br><br> - People with a history of adverse effects to the drug under study

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational [Patient Registry]
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To measure ANI values after ketamine bolus dose administration.;To determine the time maximum predicted concentrations in each patient;To determine the time to maximum effect of a bolus dose of ketamine;To predict ketamine plasma concentrations values after ketamine bolus;To calculate the difference between the time of maximum ANI effect

Secondary Outcome Measures

Name	Time	Method
Patient weight