Assessment of patients with pulmonary hypertension using cardiopulmonary exercise testing

Not Applicable

• Conditions: To investigate cardiopulmonary responses to exercise in Thai patients with idiopathic pulmonary arterial hypertension (IPAH), systemic sclerosis- associated pulmonary arterial hypertension (SSc- associa; PAH, CPET

• Registration Number: TCTR20171229001
• Lead Sponsor: Research Affair Faculty of Medicine Khon Kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-12-29
• Study Completion: 2018-10-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Age more than 20 years old
2. Subjects with diagnosis of RHC
3. Diagnosis of systemic sclerosis by rheumatologist according to systemic sclerosis guidelines (van den Hoogen et al., 2013)
4. Diagnosis of CTEPH according to the PH guidelines (Galiè et al., 2015) by cardiologist and hematologist

Exclusion Criteria

1. Unwillingness or inability to perform the testing procedure
2. Subjects with a history of cardiovascular disease (i.e. coronary heart disease, chronic HF and myocardial infarction) within 3 months before test
3. Subjects with a history of systemic infections within 3 months before test
4. Subjects with symptoms of respiratory tract infection within 6 weeks prior to the study
5. Subjects with absolute contraindications of CPET
6. Subjects with type 2, 3, or 5 PH
7. SSc patients who cannot use treadmill due to conditions such as painful, ischemic ulcers, active myositis, extremity contracture, severe malnutrition, and polyneuropathy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
gas exchange promptly CPET parameters

Secondary Outcome Measures

Name	Time	Method
T-proBNP promptly Blood sample