Validation of athe conchotome percutaneous technique to perform a muscle biopsy to measure biochemical parameters in mitochondrial disease

Completed

• Conditions: energy metabolism disturbance; mitopathy; 10021605

• Registration Number: NL-OMON34211
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- Age 0 - 18 years
- Approximately symmetrical use of both legs

Exclusion Criteria

- Age > 18 years
- Assymatrical use of one leg, for example hemiparesis

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome parameter<br /><br>ATP production in muscle</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Substrate oxidation rates in muscle cells<br /><br>Enzyme complex activities in muscle cells<br /><br>Complications of muscle biopsy</p><br>