fever illness surveillance with special attention to dengue and chikungunya

Not Applicable

Recruitment & Eligibility

Inclusion Criteria

Individuals currently residing and

likely to stay till the end of one

year in the study area.

Consented to participate in both

sections of the study (Sero -

Prevalence and AFI Surveillance)

and follow all procedures.

Exclusion Criteria

Ongoing fever episodes or history of AFI on or before enrolment for the cohort

Primary Outcome Measures

Name	Time	Method
Age specific attack rate The proportion of individuals per age strata who show <br/ ><br>Sero conversion between two rounds <br/ ><br>2 Age-specific cumulative incidence of <br/ ><br>asymptomatic infections <br/ ><br> <br/ ><br>The proportion of individuals per age strata who show <br/ ><br>seroconversion over 1 year but do not report any <br/ ><br>symptoms suggestive of the infection during AFI/ILI <br/ ><br>surveillance <br/ ><br> <br/ ><br>3 Age-specific cumulative incidence of <br/ ><br>symptomatic events <br/ ><br> <br/ ><br>The proportion of individuals reported / diagnosed with <br/ ><br>disease under surveillance <br/ ><br> <br/ ><br>4 Age Specific sero prevalence and sero <br/ ><br>incidence of neutralizing antibodies <br/ ><br> <br/ ><br>The proportion of individuals showing presence of <br/ ><br>neutralizing antibodies at baseline and at end line.Timepoint: at end of one year

Secondary Outcome Measures

Name	Time	Method
Symptomatic proportion of cases <br/ ><br>(asymptomatic fraction) <br/ ><br> <br/ ><br>The proportion of individuals who show symptoms or <br/ ><br>signs of Dengue / Chikungunya infection <br/ ><br> <br/ ><br>6 Prevalence and incidence of Circulating <br/ ><br>serotypes <br/ ><br> <br/ ><br>The proportion of symptomatic and asymptomatic <br/ ><br>cases with type of circulating serotype. <br/ ><br>7 Population groups most at risk The identification of groups who are most vulnerable to <br/ ><br>Dengue ad Chikungunya infection (e.g. age groups, <br/ ><br>gender, occupation) <br/ ><br>8 Validity of IgG ELISA The sensitivity and specificity of IgG ELISA will be <br/ ><br>calculated against PRNT (Neutralizing antibodies).Timepoint: at end of one year