Six-week high-intensity exercise program for middle-aged patients with knee osteoarthritis: a randomized controlled trial

Completed

• Conditions: Knee osteoarthritis; Musculoskeletal Diseases; Osteoarthritis (OA)

• Registration Number: ISRCTN20244858
• Lead Sponsor: The Swedish Rheumatism Association (Sweden)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-08-16
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 61

Inclusion Criteria

1. Aged 35 - 65 years
2. Living in a defined geographic area
3. Diagnosis of radiographic knee osteoarthritis according to Kellgren & Lawrence grade III or more (i.e joint space narrowing and definite osteophytes)

Exclusion Criteria

1. Inflammatory joint disease
2. Anterior cruciate ligament injury
3. Known symptomatic injury to the menisci
4. Hip symptoms more aggravating than the knee symptoms
5. About to have knee replacement surgery within 6 months
6. Co-morbidities not allowing exercise

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Knee injury and Osteoarthritis Outcome Score (KOOS, a disease specific questionnaire, assessing pain, other symptoms, activities of daily living, sport and recreation function and knee-related quality of life). Time points of interest were 6 weeks and 6 months.

Secondary Outcome Measures

Name	Time	Method
1. 36-item short form health survey (SF-36, a generic measure of general health status)<br>2. Five tests of functional performance: <br>2.1. Åstrands bicycle-ergometre test<br>2.2. Rising on one leg from sitting on lowest possible height<br>2.3. One-leg hop<br>2.4. Lateral step-up<br>2.5. One-leg semi squatting<br>2.6. Heel-rising on one leg