Comparison of two new endoscopic techniques (endoscopic tri-modality imaging and chromoendoscopy-guided confocal laser endomicroscopy) with respect to their accuracy in colonoscopic surveillance in patients with ulcerative colitis.
- Conditions
- - surveillance, dysplasia. ulcerative colitis, chromoendoscopy, confocal laser endomicroscopy (CLE), autofluorescence, narrow-band imaging- surveillance, dysplasie, colitis ulcerosa, chromoendoscopie, confocale laser endomicroscopie (CLE), autofluorescentie, narrow-band imaging
- Registration Number
- NL-OMON25794
- Lead Sponsor
- Academic Medical Centre, University of Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 235
Inclusion Criteria
1. History of UC;
2. Longstanding disease: extensive colitis >8 years; or left-sided colitis >15 years;
Exclusion Criteria
1. Personal history of (partial) colectomy;
2. Contraindications for the use of intravenous fluorescein (allergy, pregnancy or breastfeeding, severe cardiopulmonary disease or renal failure);
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diagnostic accuracy (defined as sensitivity, specificity and overall accuracy) of AFI plus NBI vs. CCLE for the differentiation of neoplastic and non-neoplastic mucosa, using final histopathology as reference standard diagnosis.
- Secondary Outcome Measures
Name Time Method