Clinical and Laboratory Assessment of Iron Overload in Sickle Cell Anemia and Sickle Cell Thalassemia

Completed

• Conditions: Sickle Cell Anemia; Sickle Cell Thalassemia
• Interventions: Other: Laboratory analyses of iron overload

• Registration Number: NCT00512564
• Lead Sponsor: HaEmek Medical Center, Israel

Brief Summary

Iron overload is well study in Thalassemia patients and it's not only related to blood transfusions, since intestinal iron absorption is also increased in those patients. Sickle cell patients didn't developed significant clinical symptoms and signs of iron overload in spite frequent transfusions. The purpose of this study is to assess the iron overload in Sickle cell anemia and Sickle cell Thalassemia patients using clinical parameters and laboratory studies including Non Transferrin Binding Iron, Labile Iron and Hepcidin, in order to determine the cardiac and liver iron.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2007-08-05
• Study First Submitted QC: 2007-08-06
• Study First Posted: 2007-08-07
• Study Start: 2008-09
• Primary Completion: 2010-12
• Study Completion: 2010-12
• Status Verified: 2011-08
• Last Update Submitted: 2011-08-25
• Last Update Posted: 2011-08-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• All the patients with Sickle Cell Anemia and Sickle Cell Thalassemia that are treated and followed up at the Pediatric Hematology Unit.

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	Laboratory analyses of iron overload	Patients suffering from Sickle cell disease

Trial Locations

Locations (1)

Pediatric Hematology Unit - HaEmek Medical Center; 🇮🇱 Afula, Israel