Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell Thalassemia

Not Applicable

Completed

• Conditions: Sickle Cell Anemia; Sickle Cell Thalassemia; Iron Overload; MRI

• Registration Number: NCT00512226
• Lead Sponsor: HaEmek Medical Center, Israel

Brief Summary

Iron overload is well study in Thalassemia patients and it's not only related to blood transfusions, since intestinal iron absorption is also increased in those patients. Sickle cell patients didn't develope significant clinical symptoms and signs of iron overload in spite frequent transfusions. The purpouse of this study is to assess the iron overload in Sickle cell anemia and Sickle cell Thalassemia patients using clinical parameters and cardiac T2\*MRI in order to determine the cardiac and liver iron.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2007-08-05
• Study First Submitted QC: 2007-08-06
• Study First Posted: 2007-08-07
• Study Start: 2007-09
• Primary Completion: 2010-12
• Study Completion: 2010-12
• Status Verified: 2011-08
• Last Update Submitted: 2011-08-25
• Last Update Posted: 2011-08-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• All the patients with Sickle cell anemia and Sickle cell Thalasemia that are currently in follow up at the Pediatric Hematology Unit

Exclusion Criteria

• Age below 18 years.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Assessment of Iron overload.	December 2008

Secondary Outcome Measures

Name	Time	Method
Institute the criteria for iron chelator treatment	December 2008

Trial Locations

Locations (1)

Pediatric Hematology Unit and Pediatric Dpt B - HaEmek Medical Center; 🇮🇱 Afula, Israel