Optimization of Desflurane in Elderly Patients Compared With Sevoflurane: A Pilot Study
Overview
- Phase
- Phase 1
- Intervention
- Desflurane
- Conditions
- Postoperative Cognitive Dysfunction
- Sponsor
- Sapporo Medical University
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- The Time From the End of Anesthesia to Extubation
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Various issues had been pointed out when undergoing the anesthesia for elderly patients with sevoflurane, such as delayed emergence, post-operative trouble with swallowing.
Desflurane, which has a lower blood/gas partition coefficient, is expected to contribute the better emergence, along with the recent progress on optimization of delivered amount of anesthesia.
The purpose of this study is to compare the time to emergence in long elderly patient cases with desflurane or sevoflurane, with the recently developed drug-delivery optimization system "Aisys®" (GE Healthcare Japan).
Detailed Description
The objectives of this study is to compare the time to emergence and quality of recovery in long elderly patient cases with desflurane or sevoflurane, with the recently developed drug-delivery optimization system "Aisys®" (GE Healthcare Japan). Inclusion Criteria: - Elderly patients (\>= 65 yr-old), long operation (\> 4hours), abdominal surgery patients Exclusion Criteria: - Liver dysfunction, Renal dysfunction, preoperative dementia Neurosurgery patients, Cardiac surgery patients, obese patients(BMI\>35)
Investigators
Michiaki Yamakage
Optimization of Desflurane in Elderly Patients Compared with Sevoflurane: A Pilot Study
Sapporo Medical University
Eligibility Criteria
Inclusion Criteria
- •Elderly patients (\>= 65 yr-old), long operation (\> 4hours), abdominal surgery patients
Exclusion Criteria
- •Liver dysfunction, Renal dysfunction, preoperative dementia Neurosurgery patients, Cardiac surgery patients, obese patients(BMI\>35)
Arms & Interventions
group DES
The patients in this arm will be given the general anesthesia with desflurane and be used the Aysis as the anesthetic machine.
Intervention: Desflurane
group SEVO
The patients in this arm will be given the general anesthesia with sevoflurane and be used the Aysis as the anesthetic machine.
Intervention: Sevoflurane
Outcomes
Primary Outcomes
The Time From the End of Anesthesia to Extubation
Time Frame: Within 60 minutes after the end of anesthesia
When surgery ends, the fresh gas flow rate will be increased to 6L/min (100% oxygen). Patients will be asked to open eyes by touching the shoulder, calling the name every 15 seconds. Patients will be applied stimulus every 15 seconds until following commands. Extubation will be performed when the patient is judged to be awake and spontaneous breathing recovery substantially.
Secondary Outcomes
- The Incidence of Postoperative Delirium(from 15 minutes to 48 hrs postoperatively)
- The Time From the End of Anesthesia to Following Commands(Within 60 minutes after the end of anesthesia)
- Cognitive Function(24 hrs pre and postoperatively)
- The Time From the End of Anesthesia to Eye Opening(Within 60 minutes after the end of anesthesia)