Study of AGN-190584 Eye Drops to Assess Safety and Efficacy in Participants Aged 40-80 Years With Pseudophakic Presbyopia
- Conditions
- Presbyopia
- Interventions
- Drug: VehicleDrug: AGN-190584
- Registration Number
- NCT05393089
- Lead Sponsor
- Allergan
- Brief Summary
Presbyopia is a condition in which the eye exhibits a diminished ability to focus on near objects with increasing age. This study will assess the safety and exploratory efficacy of AGN-190584 is in treating participants with pseudophakic presbyopia.
AGN-190584 is approved (in the United States) for use in adults with presbyopia (including those who are pseudophakic) and this study is being conducted to better understand the safety and efficacy in the pseudophakic presbyopia population. This study is double-masked meaning that neither the participants nor the study doctors will know who will be given AGN-190584 and who will be given vehicle (does not contain treatment drug). Study doctors put the participants in 1 of the 2 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 3 chance that participants will be assigned to vehicle. Approximately 150 participants aged 40-80 years with pseudophakic presbyopia will be enrolled in approximately 30 sites in the US.
Participants will receive eye drops of AGN-190584 or vehicle once daily in the morning in each eye for 14 days.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study. The effect of the treatment will be evaluated by medical assessments, checking for side effects and completing questionnaires.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- History of bilateral pseudophakia with monofocal intraocular lenses corrected for distance (noncomplicated cataract surgery), with identifiable intraocular lens type/brand, at least 3 months after surgery (prior to baseline), and be in stable condition.
- If a participant has had neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy, it needs to be done bilaterally at least 1 month prior to baseline.
- Subjective complaints of poor near vision that impacts activities of daily living, as defined by at least a moderate impact (score >= 3) on at least 1 question on 25-Item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) Questions 5 to 7 in the main questionnaire or Near Vision Subscale, Questions A3 to A5 in the Appendix of Optional Additional Questions at the screening visit.
- Best distance correction at screening in the range of spherical -1.50 D to +1.00 D inclusively and cylinder <= ±2.00 D with photopic high contrast binocular corrected distance visual acuity (CDVA) of 20/25 or better at the screening and baseline visits.
- Mesopic, high contrast binocular distance-corrected near visual acuity (DCNVA) no better than 20/40 (J3) at screening and baseline visits.
- Presence of any ocular condition that, in the opinion of the investigator, could affect the safety of the participant or interpretation of efficacy parameters (e.g., uveitis, acute iritis, retinal detachment or retinal tear).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Vehicle Vehicle Participants will receive one drop of vehicle instilled in each eye once daily for 14 days. AGN-190584 AGN-190584 Participants will receive one drop of AGN-190584 instilled in each eye once daily for 14 days.
- Primary Outcome Measures
Name Time Method Number of Participants Experiencing Adverse Events (AEs) Up to approximately 14 days An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment. The investigator assesses the relationship of each event to the use of study.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (32)
Global Research Management /ID# 243544
🇺🇸Glendale, California, United States
United Medical Research Institute /ID# 243531
🇺🇸Inglewood, California, United States
Salvay Vision /ID# 243828
🇺🇸Newport Beach, California, United States
The Eye Research Foundation /ID# 243524
🇺🇸Newport Beach, California, United States
Sacramento Eye Consultants /ID# 243538
🇺🇸Sacramento, California, United States
Segal Drug Trials, Inc /ID# 243521
🇺🇸Delray Beach, Florida, United States
Arizona Eye Center /ID# 243897
🇺🇸Chandler, Arizona, United States
Levenson Eye Associates Inc. /ID# 243532
🇺🇸Jacksonville, Florida, United States
Kannarr Eye Care /ID# 243542
🇺🇸Pittsburg, Kansas, United States
Key-Whitman Eye Center /ID# 243928
🇺🇸Dallas, Texas, United States
Eye associates /ID# 243526
🇺🇸San Antonio, Texas, United States
Cincinnati Eye Institute- Edgewood /ID# 243810
🇺🇸Edgewood, Kentucky, United States
EyeCare Professionals Inc /ID# 243938
🇺🇸Powell, Ohio, United States
Scott and Christie and Associates /ID# 243548
🇺🇸Cranberry Township, Pennsylvania, United States
Silverstein Eye Centers /ID# 243546
🇺🇸Kansas City, Missouri, United States
University Eye Surgeons /ID# 243926
🇺🇸Maryville, Tennessee, United States
Advancing Vision Research /ID# 243529
🇺🇸Smyrna, Tennessee, United States
Fraser Eye Center /ID# 244038
🇺🇸Fraser, Michigan, United States
Country Hills Eye Center /ID# 243520
🇺🇸Ogden, Utah, United States
Hoopes, Durrie, Rivera Research /ID# 243535
🇺🇸Draper, Utah, United States
Southern Utah Medical Research /ID# 243931
🇺🇸Saint George, Utah, United States
Clayton Eye Clinical Research, LLC /ID# 243530
🇺🇸Morrow, Georgia, United States
Coastal Research Associates /ID# 243525
🇺🇸Roswell, Georgia, United States
Emory University /ID# 243534
🇺🇸Atlanta, Georgia, United States
Nature Coast Clinical Research - Crystal River /ID# 243519
🇺🇸Crystal River, Florida, United States
Rochester Ophthalmological Group PC /ID# 243539
🇺🇸Rochester, New York, United States
The Eye Care Institute /ID# 243588
🇺🇸Louisville, Kentucky, United States
Parkhurst Nuvision /ID# 244041
🇺🇸San Antonio, Texas, United States
Eye Associates of North Jersey /ID# 243913
🇺🇸Dover, New Jersey, United States
Northern New Jersey Eye Institute PA /ID# 243522
🇺🇸South Orange, New Jersey, United States
Trinity Research Group /ID# 243541
🇺🇸Dothan, Alabama, United States
Eye Associates of Fort Meyers /ID# 243545
🇺🇸Fort Myers, Florida, United States