Comparision of potency of muscle relaxant â??vecuroniumâ?? during isoflurane anesthesia and nitrous oxide anesthesia
Not Applicable
- Conditions
- Health Condition 1: null- ASA1 and 2 patients, of age between 18-65yrs ,undergoing surgery for more than 1 hr
- Registration Number
- CTRI/2018/03/012704
- Lead Sponsor
- Jawaharlal institute of postgraduate education and research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Adult patients undergoing elective surgical procedures of more than one hour duration, requiring general anesthesia with muscle relaxation
Exclusion Criteria
1. Patientâ??s refusal.
2. Patients with hepatic or renal dysfunction.
3. Patients with neuromuscular disorders.
4. Patients on medication that may alter neuromuscular transmission.
5.Pregnant patients and patients above 65 years of age.
6. Contraindication to nitrous oxide, isoflurane or vecuronium
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method sing neuro muscular monitoring,To assess and compare neuromuscular blockade of vecuronium during general anaesthesia with O2,N2O and isoflurane versus O2,air and isoflurane.Timepoint: PTC1-TOF1
- Secondary Outcome Measures
Name Time Method sing neuro muscular monitoring,To assess and compare 1. block onset time of vecuronium in both the groups using the time taken for twitch height depression to become 30% of normal <br/ ><br>2. from vecuronium administration to first appearance of PTC 1 <br/ ><br>3. PTC (n) at reappearance of 1st twitch in both the groups <br/ ><br>4.time interval between TOF 1 and TOF 3 <br/ ><br> 5.from vecuronium administration to appearance of TOF 3Timepoint: post tetanic count-1(PTC1), Train of four-TOF1,TOF3,TOF1-TOF3.