Cartilage turnover and changes in inflammatory biomarkers and its correlation with clinical efficacy after intra-articular and intra-osseous Platelet Rich Plasma Injections in Osteoarthritis: Randomized Controlled Clinical Trial

Indian Council Medical Research0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•The diagnosis of OA will be based on the American College of Rheumatology (ACR) criteria for OA Knee. Persons with OA Knee with the following features will be included in the study
•1) OA Knee (Grade II/III, Radiological Kellgren and Lawrence (K/L) classification), age between 40-65 years and are able to walk with painful knee,
•2)Having persisting knee pain >= 30mm on a 0-100mm VAS (when asked â??how painful is your knee during level walking?â??),
•3)Willing to participate in all assessment
•If both knees involved, participants may choose one or both knees to be treated.

•Persons with OA Knee with following features will be excluded from the study
•1.Severe OA Knee (Grade IV, K/L classification)
•2.Haemoglobin level < 10gm%
•3.Inflammatory or post-infectious knee arthritis
•4.History of prior knee replacement or repair
•5.Prior fracture of the knee joint
•6.Any Knee injection within 3 months
•7.Daily use of opioid medication
•8.Coexisting backache, other chronic pain disorder
•9.Body mass index (BMI) >=40 kg/m2
•10.Blood disorders, hematological, cardiac, hepatic or renal disorders.
•11.Persons who receive oral, topical or intra-articular steroid last four weeks, pregnancy

发起方

Indian Council Medical Research