Visualizing Cartilage and Joint Homeostasis Changes after Knee Joint Distraction using the META-Scanner and Synovial Fluid Aspirations*
Withdrawn
- Conditions
- cartilage degenerationosteoarthritis10023213
- Registration Number
- NL-OMON48274
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Patients with knee joint degeneration (osteoarthritis) eligible in regular
clinical practice for knee joint distraction.
In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
- Good knowledge of the Dutch language
- Signed informed consent
Exclusion Criteria
A potential subject who meets any of the following criteria will be excluded
from participation in this study:
- Not eligible for MRI, in response to the MRI safety checklist
- Metal present in the treated knee
- Knee width > 14 cm
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The changes in GAG content of the cartilage;<br /><br>the changes in joint homeostasis that facilitates cartilage repair after knee<br /><br>joint distraction, with a focus on growth factors, proteases, pro-inflammatory<br /><br>cytokines, and mesenchymal stem cells;<br /><br>the changes in sodium concentration of the cartilage.</p><br>
- Secondary Outcome Measures
Name Time Method <p>* Relation between imaging parameters and synovial fluid changes</p><br>