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临床试验/NCT02719457
NCT02719457Unknown不适用

the Relationship Between Spot Marching Exercise Test and Six Minute Walk Test in Patient With Chronic Obstructive Pulmonary Disease

Khon Kaen University4 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2016年4月最近更新:
适应症

试验速览

阶段
不适用
入组人数
30
试验地点
4
主要终点
number of step of Spot Marching Test

研究概览

简要总结

the aim of this study to assess the relationship and compare physiological response between spot marching exercise test and 6 minute walk test in patient with chronic obstructive pulmonary disease

详细描述

Chronic obstructive pulmonary disease (COPD) is caused by airway inflammation (increase airway resistance) and destroyed of alveoli (decrease elastic recoil) leading to air trapping (GOLD, 2013). Dyspnea is the most symptom of COPD, a consequence of air trapping. Furthermore, inflammation of COPD has not only been assessed in the airways and lung compartment, but also in the systemic circulation that so called "systemic effects of COPD" such as skeletal muscle atrophy and dysfunction and cardiovascular disease (Wouter, 2002). The occurrence of dyspnea and systemic effects of COPD result in activity and exercise limitation when disease progressive downward.

Exercise testing is the most common determination of exercise limitation and responsiveness of intervention in COPD. It has several exercise protocols including laboratory test and field test. Both test aim to investigate exercise capacity but laboratory test have more parameter detail than field test. In 2013 Borel et al, classified the exercise protocols into three categories by using the workload characteristic (incremental or constant) and the self-paced test. Self-paced test was developed to solve the disadvantage of Incremental and Constant work rate (laboratory test). Moreover,it reflect functional activity and is easy to use. Self-paced test that most famous test such as six minute walk test, step test and stepper test Six minute walk test (6-MWT) assesses distance walked as far as possible within 6 minutes on straight courses. Although the 6-MWT is the most reliable, but it is impractical (Kocks et al., 2011) because of environmental constrain (this test should be performed wild area).

Step test was performed in small area such as hospitals and physician's office. However, these protocols have a risk of falling. Therefore, it was unsuitable for patients who have the imbalance or articular problem.

In 2010, Borel et al., developed six-minute stepper test (6-MST) to solve problem of 6MWT and step test. This study reported that 6-MST used oxygen consumption (VO2) lower than 6MWT. They reasoned that during stepper test, subject move upper limb fewer than walking test. Similarly with Mayo et al., 2001, they found heart rate and expiratory minute ventilation (VE) response of arm performance higher than leg. Therefore, movement of the upper limbs may be increase VO2 peak during exercise test of COPD patient.

Exercise limitation in COPD patient is not only occurs in lower body activity but also occurs during upper task due to systemic effect of disease. Upper body activity was used in daily activity such as lifting, bathing and washing. The almost protocols of exercise test were focused on lower limb test.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
盲法
None

入排标准

年龄范围
35 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • mild to very severe COPD patients

排除标准

  • Exacerbate within a month prior, which was a cause of admission to the hospital emergency room or been admitted to hospital.
  • Are changed medicines within a month ago.
  • Have been used home oxygen therapy.
  • Have musculoskeletal or neuromuscular problem affecting balance and walking.
  • Using walking aid device.

结局指标

主要结局

number of step of Spot Marching Test

时间窗: up to 6 min

次要结局

  • Heart rate(every minute at pre-exercise for 5 min, during exercise test for 6 min and recovery phase for 10 min)
  • partial pressure of end tidal carbondioxide(every minute at pre-exercise for 5 min, during exercise test for 6 min and recovery phase for 10 min)
  • distance of 6 minute walk test(up to 6 min)
  • Respiratory rate(every minute at pre-exercise for 5 min, during exercise test for 6 min and recovery phase for 10 min)
  • Blood pressure(up to 2 minute in recovery phase)
  • number of step of 6 minute walk test(up to 6 min)
  • Electrocardiogram (lead II)(every minute at pre-exercise for 5 min, during exercise test for 6 min and recovery phase for 10 min)
  • peripheral oxygen saturation (SpO2)(every minute at pre-exercise for 5 min, during exercise test for 6 min and recovery phase for 10 min)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Vatcharaporn Khaweephab

Khon Kaen Hospital

Khon Kaen University

研究点 (4)

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