Mechanistic Underpinnings of Preeclampsia

Not yet recruiting

• Conditions: Preeclampsia

• Registration Number: NCT06567899
• Lead Sponsor: University of Arizona

Brief Summary

Preeclampsia is a dreadful disease with significant morbidity and mortality. Despite decades of research, we still need a proper diagnostic test or therapeutic option to treat this disorder. The proposed study will determine the diagnostic value of PBMC-secreted sFlt1 and determine the molecular mechanisms involved in its secretion. The molecular mechanisms can be novel therapeutic targets to treat this disorder.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-05-29
• Status Verified: 2024-08
• Study First Submitted QC: 2024-08-19
• Study First Posted: 2024-08-23
• Last Update Submitted: 2024-11-21
• Last Update Posted: 2024-11-25
• Study Start: 2025-01-25
• Primary Completion: 2025-12-31
• Study Completion: 2028-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 500

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
sFLT1 levels	Outcome will be measured at 12 weeks, 24 weeks and 36 weeks of pregnancy.	sFLT1 levels in preeclampsia should be higher than normal pregnancy.