Mechanistic Underpinnings of Preeclampsia

Not yet recruiting

• Conditions: Preeclampsia

• Registration Number: NCT06567899
• Lead Sponsor: University of Arizona

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-5-29
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Not yet recruiting
• Sex: Female
• Target Recruitment: 500

Inclusion Criteria

Healthy Adults:<br><br>• Healthy non-pregnant with previous normal pregnant women<br><br>Non-Health Adults:<br><br>• Patients will be admitted with the diagnosis of preeclampsia according to the<br>internationally accepted definition of preeclampsia: Blood pressure measurement of 140/90<br>mm Hg or an increase of 30 mm Hg systolic or 15 mm Hg diastolic over baseline values on<br>at least two occasions, six or more hours apart and proteinuria; 300 mg/24 hour after<br>20th week of gestation.<br><br>Pregnant Women:<br><br>Groups 3 - 6 will include pregnant women at different trimesters.<br><br>Criteria common to all groups:<br><br> - The study will be conducted only in females aged 18 or above.<br><br> - Patients in all the groups will be matched for age, which will be 18 or above.<br><br> - Women will be matched for body mass index; criteria for normal body mass index will<br> be used based on the Center for Disease Control and Prevention Guidelines.<br><br> - Patients with premature rupture of the membrane, non-preeclamptic preterm labor,<br> IUGR, placental abruption, twin? Any other complications during the pregnancy will<br> be excluded from the study.<br><br> - Patients with any evidence of genetic or non-genetic malformations of the fetus will<br> be excluded from the study.<br><br> - The study will be conducted on women who are non-smokers and do not consume alcohol<br> or recreational drugs.<br><br> - The study will be conducted only on primigravida females to minimize phenotyping<br> variability.<br><br> - The women with a known history of any chronic disorder, including but not limited to<br> hypertension, diabetes, pulmonary, renal, cardiac, or cerebrovascular disorders,<br> will be excluded from the studies.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
sFLT1 levels