Analysis of Respiratory System Mechanics and Inflammatory Response During Orthotopic Liver Transplantation (SPPLIT Trial)
- Conditions
- End Stage Liver Diseases
- Registration Number
- NCT02119585
- Lead Sponsor
- University of Turin, Italy
- Brief Summary
During orthotopic liver transplantation (OLT), respiratory system function may be severely impaired for several reasons including anaesthesia effects, hyperdynamic volume state with fluid overload and ischemia reperfusion injury. In particular, reperfusion syndrome is characterised by the release of several inflammatory mediators such as cytokines and oxygen free radicals which may contribute to alveolar endothelial barrier dysfunction. The object of this study is to investigate the respiratory system mechanics impairment in its partitioning between lung and chest wall.
We hypothesize that impairment of respiratory system mechanics (of both lung and chest wall) occurs after reperfusion phase of liver. This impairment is associated with the systemic inflammatory response following liver reperfusion.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
- orthotopic liver transplantation
- valid informed consent
- Age < 18 yrs
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Elastance of Respiratory System, Lung and Chest Wall at 24 hours after liver reperfusion
- Secondary Outcome Measures
Name Time Method Inflammatory mediators in plasma samples baseline, 90 minutes, 3 hours and 24 hours after reperfusion phase Inflammatory mediators in urine samples baseline, 90 minutes, 3 hours and 24 hours after reperfusion phase Acute respiratory failure 28 days hospital length of stay 28 days Ventilator free days 28 days ICU length of stay 28 days
Trial Locations
- Locations (1)
Azienda Ospedaliera Città della Salute e della Scienza di Torino
🇮🇹Turin, Italy